"Wise Blood" is a novel about a young man named Hazel Motes, who returns home to Tennessee after serving in World War II and finds his religious beliefs shaken. He becomes a street preacher, founding the Church Without Christ to preach his message of faithlessness. The book explores themes of redemption, faith, and the struggle between belief and atheism as Hazel interacts with a variety of eccentric characters and faces his own internal battles.

This novel revolves around an advice columnist, who writes under the pseudonym "Miss Lonelyhearts", for a New York newspaper during the Great Depression. As he reads and responds to the desperate letters from the city's distressed and downtrodden, he becomes increasingly disillusioned and depressed, struggling with his own faith, identity, and the bleakness of the human condition. The protagonist's personal life also spirals out of control, entangling him in a series of complicated romantic relationships and leading to a tragic conclusion.

The novel is a dystopian narrative set in a future where a new Asian empire has conquered Europe. The story follows a young Polish man who, while initially indulging in hedonistic pursuits, becomes increasingly disillusioned with the world around him. As the new empire introduces a mysterious substance known as Murti-Bing pills, which create a sense of contentment and indifference in the populace, the protagonist grapples with the loss of individuality and the erosion of human spirit in society. The narrative is a critique of totalitarian regimes and the dangers of mass conformity.

The narrative centers around an elderly man who has spent his life compacting paper and books into bales in a decrepit cellar, using a hydraulic press. Despite the menial nature of his job, he has cultivated a deep love and profound knowledge for literature, philosophy, and art from the books that pass through his hands, many of which he rescues from destruction. The story is a poignant exploration of the power and resilience of the human spirit in the face of a dehumanizing, totalitarian regime, and a meditation on the enduring value of art and the written word. The protagonist's intellectual journey and his resistance to the oppressive forces around him serve as a metaphor for the survival of culture and individuality under oppressive conditions.