"The Women's Room" is a groundbreaking novel that explores the journey of a suburban housewife from a traditional, oppressive marriage to an awakening of self-discovery and feminism. After her divorce, the protagonist goes back to school, where she encounters a group of independent, intellectually stimulating women who challenge the societal norms of the time. The novel provides a stark portrayal of the struggles faced by women in the 1950s and 1960s, highlighting the need for gender equality and women's rights.

The novel is a reflective account of the life of Harry Pulham, a middle-aged, conventional Bostonian who is prompted to examine his past and the choices he has made during the process of writing a Harvard class reunion biography. As he delves into his memories, he confronts his youthful ambitions, his experiences in World War I, and his complex relationships, particularly with a vivacious woman who challenged the conservative values of his upbringing. Through this introspection, Harry grapples with the realization that he has conformed to societal expectations at the expense of his own happiness, leading to a poignant exploration of the conflict between individual desires and societal pressures in early 20th-century America.