The novel explores the complexities of marriage and divorce in the late 19th century through the story of Bartley and Marcia Hubbard, a young couple from a small New England town. As Bartley's journalistic career takes off, his moral shortcomings and infidelity strain the marriage, leading to a tumultuous relationship. The narrative delves into the social and personal consequences of their failing marriage, highlighting the challenges of adhering to societal expectations and the impact of personal choices on the lives of individuals and their communities. The book is a critical examination of the institution of marriage, the evolving roles of men and women, and the pursuit of happiness in the face of societal pressures.

The novel is a reflective account of the life of Harry Pulham, a middle-aged, conventional Bostonian who is prompted to examine his past and the choices he has made during the process of writing a Harvard class reunion biography. As he delves into his memories, he confronts his youthful ambitions, his experiences in World War I, and his complex relationships, particularly with a vivacious woman who challenged the conservative values of his upbringing. Through this introspection, Harry grapples with the realization that he has conformed to societal expectations at the expense of his own happiness, leading to a poignant exploration of the conflict between individual desires and societal pressures in early 20th-century America.