The novel tells the story of Gogol Ganguli, a second-generation Indian-American, who struggles with his unique name and his dual cultural identity. Born to immigrant parents from Kolkata, India, Gogol is named after the famous Russian author, Nikolai Gogol, a decision that shapes his life in unexpected ways. As he grows up, he finds himself torn between his parents' traditional Indian values and his desire to fit into mainstream American society. This internal conflict is further complicated by his relationships with women of different cultural backgrounds. The book explores themes of identity, cultural assimilation, and the immigrant experience.

"Family Pictures" is a poignant narrative that delves into the complexities of family life, centering around a seemingly perfect family that is forever altered by the diagnosis of one of the children with autism. The story unfolds over decades, exploring the profound impact of the child's condition on each family member's life and relationships. As secrets and tensions surface, the novel examines themes of love, responsibility, and the enduring bonds of family amidst the challenges of raising a child with special needs. The narrative provides a deep and empathetic look at the sacrifices and joys inherent in family dynamics, and the ways in which personal crises can both fracture and fortify the connections between relatives.

The novel centers on Nora Eldridge, an elementary school teacher in Cambridge, Massachusetts, who once dreamed of becoming an artist. Now in her late thirties, she feels the bitter sting of unfulfilled dreams and is often referred to as the "woman upstairs" due to her quiet, unobtrusive existence. Her life takes a dramatic turn when she becomes enamored with the Shahid family—Skandar, a Lebanese scholar, Sirena, an Italian artist, and their son, Reza, who becomes one of Nora's students. As Nora becomes increasingly entangled in the Shahid's charismatic and sophisticated world, she is awakened to new emotions and ambitions, but this infatuation leads her down a path of passion, betrayal, and a reexamination of her own identity and desires. The novel is a deep exploration of the themes of art, womanhood, and the complexities of the inner life.

The novel follows a group of Cambridge philosophy students under the guidance of their enigmatic and often perplexing lecturer, whom they nickname Wittgenstein Jr due to his philosophical intensity and resemblance to the famous philosopher. Throughout the academic year, the students grapple with their own intellectual and existential crises while being drawn into their lecturer's personal quest to forge a philosophical path that both honors and challenges the legacy of his namesake. The narrative weaves together themes of youth, academia, and the struggle for meaning in a style that is both humorous and deeply reflective.