The novel tells the story of Gogol Ganguli, a second-generation Indian-American, who struggles with his unique name and his dual cultural identity. Born to immigrant parents from Kolkata, India, Gogol is named after the famous Russian author, Nikolai Gogol, a decision that shapes his life in unexpected ways. As he grows up, he finds himself torn between his parents' traditional Indian values and his desire to fit into mainstream American society. This internal conflict is further complicated by his relationships with women of different cultural backgrounds. The book explores themes of identity, cultural assimilation, and the immigrant experience.

"Family Pictures" is a poignant narrative that delves into the complexities of family life, centering around a seemingly perfect family that is forever altered by the diagnosis of one of the children with autism. The story unfolds over decades, exploring the profound impact of the child's condition on each family member's life and relationships. As secrets and tensions surface, the novel examines themes of love, responsibility, and the enduring bonds of family amidst the challenges of raising a child with special needs. The narrative provides a deep and empathetic look at the sacrifices and joys inherent in family dynamics, and the ways in which personal crises can both fracture and fortify the connections between relatives.