"The Big Sea" is an autobiography that explores the life of a significant figure in the Harlem Renaissance. The narrative follows his early life in the Midwest, his travels around the world as a seaman, and his experiences in New York during the 1920s, where he was a central figure in the Harlem Renaissance. Throughout the book, the author offers his observations on racism, class, and the creative process, providing a vivid and insightful portrait of a complex era in American history.

The narrative revolves around the lives of two boyhood friends navigating through their complicated lives in the 1980s. One of them is a bisexual man mourning the loss of his lover to AIDS, and the other is a straight man who's been in love with his friend since childhood. Their lives intertwine with a bohemian woman who dreams of having a child. The three of them form an unconventional family, exploring the complexities of relationships, love, and the concept of home.