Set in the 1980s during the era of Margaret Thatcher's conservative government in Britain, this novel follows the life of a young gay man named Nick Guest. Coming from a middle-class background, he moves into the home of his wealthy friend's family and becomes infatuated with the opulence and power of the upper class. As he navigates his way through this new world, he also explores his sexuality, all while dealing with the societal and political implications of the AIDS crisis.

The novel follows the life of Patrick Melrose, a man battling with his drug addiction and his troubled relationship with his parents. Patrick tries to come to terms with his mother’s decision to leave her estate to a New Age foundation rather than to him, her only son. The story delves into the complexities of inheritance, parenthood, and the lasting impact of childhood trauma. The narrative shifts between the perspectives of Patrick, his wife, and their two young sons, providing a multi-dimensional view of the family's struggles.

"Shuggie Bain" is a heart-wrenching tale set in 1980s Glasgow, Scotland, centered on a young boy, Shuggie, who is struggling with his mother's deteriorating mental health and alcoholism. As he tries to navigate his own burgeoning sexuality in a harsh, unforgiving environment, he also strives to care for his mother, who is trapped in a cycle of addiction and abusive relationships. The book gives a stark portrayal of poverty, addiction, love, and the human spirit's resilience.

The novel delves into the lives of a family grappling with the impact of mental illness across generations. It explores the bonds and strains among family members as they confront the challenges posed by the eldest son's severe anxiety and depression. Through shifting perspectives, the narrative examines the ways in which each family member copes with their shared and individual struggles, illuminating the profound effects of love, loyalty, and the legacy of mental health issues on their relationships and choices. The story is a poignant and insightful portrayal of the complexities of familial love and the enduring human capacity for resilience in the face of emotional turmoil.