The novel follows the life of Billy Pilgrim, a World War II veteran who has become "unstuck in time," experiencing his life events out of order. This includes his experiences as a prisoner of war in Dresden during the Allies' firebombing, his post-war life as a successful optometrist, his abduction by aliens from the planet Tralfamadore, and his eventual death. The book is a critique of war and a demonstration of the destructive nature of time, with a nonlinear narrative that reflects the chaos and unpredictability of life.

The Baroque Cycle is an expansive historical fiction series that weaves together a rich tapestry of themes including science, politics, philosophy, and adventure during the late 17th and early 18th centuries. The narrative follows an eclectic cast of characters, ranging from natural philosophers and mathematicians to pirates and nobles, as they navigate the complex socio-political transformations of the Enlightenment era. The series delves into the origins of modern finance, the scientific revolution, and the geopolitical power shifts of the time, all while exploring the intricate interplay between the emerging modern world and the intricate, ornate culture of the Baroque period.