Set in a dystopian future, the novel explores a society where human beings are genetically bred and pharmaceutically conditioned to serve in a ruling order. The society is divided into five castes, each with its specific roles. The narrative follows a savage who rejects the norms of this new world order and struggles to navigate the clash between the values of his upbringing and the reality of this technologically advanced, emotionless society. His resistance prompts a deep examination of the nature of freedom, individuality, and happiness.

This novel unfolds in a dystopian United States where society's most productive citizens, including inventors, scientists and industrialists, refuse to be exploited by increasing social and economic demands. As a response, they withdraw their talents, leading to the collapse of the economy. The story presents the author's philosophy of objectivism, which values reason, individualism, and capitalism, and rejects collectivism and altruism. The narrative primarily follows Dagny Taggart, a railroad executive, and John Galt, a philosophical leader and inventor, as they navigate this societal breakdown.

Set in 1920s Berlin, the book follows the life of Franz Biberkopf, a man recently released from prison who is trying to make an honest life for himself. However, he is drawn back into the criminal underworld due to circumstances and the influence of his acquaintance, Reinhold. The book is a vivid portrayal of city life in Weimar-era Germany, exploring themes of poverty, crime, redemption and the struggle to maintain one's morality amidst chaos and corruption.

The novel is a disturbing and graphic exploration of the mind of a wealthy, young and handsome Wall Street investment banker who is also a psychopathic serial killer. He leads a double life, appearing to be a charming and sophisticated businessman by day, while indulging in horrific acts of violence and murder by night. The narrative provides a satirical critique of 1980s American consumer culture, vanity, and excess, while also delving into the dark underbelly of human nature.