The book is a humorous and honest portrayal of a single woman's life in London. The protagonist, a 30-something year old woman, struggles with her weight, smoking, and alcohol consumption, all while trying to navigate her love life and career. The story is told through her personal diary entries, which include her daily calorie counts, number of cigarettes smoked, and other personal anecdotes. It's a modern take on romantic relationships and self-improvement, with a healthy dose of comedy.

The novel follows a young, privileged, and carefree gay man living in London. His life of leisure is interrupted when he saves the life of an elderly man, who in return asks him to write his biography. As he delves into the man's past, he uncovers a hidden history of gay life that is much darker and less accepted than the one he is used to, challenging his understanding of personal and societal progress.

Ghostwritten is a complex, interconnected narrative that spans the globe, featuring nine different characters in nine different locations, including a cult member in Okinawa, a jazz buff in Tokyo, a British investment banker in Hong Kong, an old woman running a tea shack in China, a transmigrating spirit in Mongolia, a ghostwriter in London, a physicist in Ireland, a late-night radio DJ in New York, and a noncorporeal entity in a global network. Each story is seemingly separate, but as the novel progresses, the connections between them become more apparent, creating a web of incidents and interactions that span space and time.