The book is a collection of linked short stories narrated by a young, unnamed protagonist who struggles with drug addiction. The stories are set in various locations across the United States and are filled with surreal and sometimes violent experiences. Despite the bleak circumstances, the narrator seeks moments of beauty and grace, often finding them in unexpected places. The narrative is characterized by its disjointed chronology, hallucinatory descriptions, and dark humor.

"The Able McLaughlins" is a historical novel set in the 19th century, revolving around a Scottish immigrant family in Iowa. The story follows Wully McLaughlin, the eldest son, who returns home from the Civil War only to discover that his sweetheart, Chirstie, has been violated and is pregnant. Wully marries her to protect her honor, and sets out to find the man responsible, leading to a dramatic climax. The novel explores themes of family, honor, justice, and the immigrant experience in America.