The novel tells the story of Humbert Humbert, a man with a disturbing obsession for young girls, or "nymphets" as he calls them. His obsession leads him to engage in a manipulative and destructive relationship with his 12-year-old stepdaughter, Lolita. The narrative is a controversial exploration of manipulation, obsession, and unreliable narration, as Humbert attempts to justify his actions and feelings throughout the story.

"Affliction" is a powerful and haunting novel about a man named Wade Whitehouse, a small-town cop in New Hampshire, who descends into a spiral of violence and despair triggered by the fear of his own impotence. The narrative delves deep into Wade's past and present life, his struggles with alcoholism, his failed marriage and difficult relationship with his daughter, and his abusive father, all leading to a tragic and shocking climax. The book is a profound exploration of the struggle for self and identity in a harsh and unforgiving environment.

The novel follows the Berry family, whose eccentricities and resilience are tested over generations, particularly through their experiences running various incarnations of the eponymous hotel. From their original establishment in New England to a second in Vienna, the Berrys encounter a cast of quirky characters, endure tragedies, and navigate complex relationships. Themes of love, loss, and the pursuit of dreams are explored against a backdrop of political and social upheaval, with the family's unique motto, "Keep passing the open windows," serving as a refrain for their determination to persevere in the face of life's absurdities and challenges.

The novel intertwines two compelling narratives: one of a contemporary woman who, while on a work assignment to photograph a historic crime scene, grapples with her disintegrating marriage and an overpowering attraction to another man; and the other, a century-old tragedy of a Norwegian immigrant, whose jealousy and secrets lead to a shocking act of violence on the isolated island of Smuttynose. As the photographer delves deeper into the past, the stories converge, revealing the enduring consequences of love and jealousy.