In this engaging sequel, the protagonist, a brilliant but socially awkward geneticist, faces the challenges of impending fatherhood. After marrying Rosie, the couple relocates to New York City, where he struggles to adapt to his new life and the unexpected news that they're expecting a baby. Determined to be the perfect father, he approaches parenthood with the same meticulous research and planning that he applies to his scientific work, leading to a series of humorous and heartwarming misadventures. As he attempts to navigate the complexities of marriage and family life, he learns valuable lessons about love, friendship, and what it truly means to be a parent.