The book revolves around the Richardson family and the mysterious mother-daughter duo who move into their rental home in Shaker Heights, Ohio. The lives of the seemingly perfect suburban Richardson family become intertwined with the lives of Mia Warren, an enigmatic artist, and her daughter Pearl. As the children of both families form relationships, secrets are uncovered, leading to a dramatic climax. The novel explores themes of motherhood, identity, and the moral complexities of following rules versus following one's instincts.

"During the Reign of the Queen of Persia" is a novel that explores the lives and experiences of a group of young cousins growing up in rural Ohio during the 1950s. Narrated from the collective perspective of the girls, the story delves into their complex family dynamics, particularly focusing on the influence of their grandmother, a formidable and charismatic woman. The narrative captures the nuances of childhood and adolescence, weaving themes of identity, femininity, and the transition from innocence to awareness against the backdrop of a changing America. The novel poignantly portrays the bonds of family and the pains of growing up, offering a rich and textured glimpse into the intricacies of rural life and the enduring impact of matriarchal figures.