The novel tells the story of Saleem Sinai, who was born at the exact moment when India gained its independence. As a result, he shares a mystical connection with other children born at the same time, all of whom possess unique, magical abilities. As Saleem grows up, his life mirrors the political and cultural changes happening in his country, from the partition of India and Pakistan, to the Bangladesh War of Independence. The story is a blend of historical fiction and magical realism, exploring themes of identity, fate, and the power of storytelling.

"River of Fire" is an expansive novel that spans over 2,500 years of Indian history. The narrative unfolds through the intertwined lives of four characters who are reincarnated in different eras: a Buddhist monk in 400 B.C., a court poet in the Mughal Empire, a British colonial administrator, and a modern Indian intellectual. This literary masterpiece is a reflection on the cyclical nature of history, the continuity of life and the human spirit, and the eternal quest for freedom and identity, providing a panoramic view of the socio-political evolution of the Indian subcontinent.