The novel follows the story of a young woman who wins a guest editorship at a magazine in New York City and, after a series of personal and professional disappointments, suffers a mental breakdown and returns to her family, where she continues to struggle with depression and suicidal thoughts. The protagonist's experiences in psychiatric institutions and her attempts to reclaim her life are depicted with brutal honesty, making it a poignant exploration of mental illness and the societal pressures faced by women in the mid-20th century.

The novel is a final look into the life of Harry "Rabbit" Angstrom, a former high-school basketball star, now in his mid-fifties, overweight and grappling with several health issues. Despite his success in business, his personal life is in shambles, with his wife addicted to alcohol and his son to drugs. Harry, struggling with his mortality, is trying to understand his past and make sense of his future, while dealing with the changing American society and the consequences of his own choices.

This novel is a contemporary, multicultural exploration of family life, love, and identity. It follows the lives of two mixed-race families, the Belseys and the Kipps, who are linked by their shared professions in academia and a complex web of marital and extramarital relationships. The story is set against the backdrop of Wellington, a fictional New England town, and explores themes of race, class, and cultural clash. It also delves into the world of academia, examining the politics and conflicts that arise in that environment.

In "Boy, Snow, Bird," a young woman named Boy Novak escapes her abusive father in New York City to settle in a small town in Massachusetts, where she marries a widower and becomes stepmother to his daughter, Snow. After giving birth to her own daughter, Bird, who is dark-skinned, it is revealed that her husband and stepdaughter are light-skinned African Americans passing as white. The book explores themes of identity, beauty, and the damaging effects of racism as Boy grapples with her feelings towards Snow and Bird, and the societal implications of their different skin tones.

The novel delves into the lives of a family grappling with the impact of mental illness across generations. It explores the bonds and strains among family members as they confront the challenges posed by the eldest son's severe anxiety and depression. Through shifting perspectives, the narrative examines the ways in which each family member copes with their shared and individual struggles, illuminating the profound effects of love, loyalty, and the legacy of mental health issues on their relationships and choices. The story is a poignant and insightful portrayal of the complexities of familial love and the enduring human capacity for resilience in the face of emotional turmoil.