Set during the end of World War II, the novel follows Tyrone Slothrop, a lieutenant in the U.S. Army, as he tries to uncover the truth behind a mysterious device, the "Schwarzgerät", that the Germans are using in their V-2 rockets. The narrative is complex and multi-layered, filled with a vast array of characters and subplots, all connected by various themes such as paranoia, technology, and the destructive nature of war. The book is known for its encyclopedic nature and its challenging, postmodernist style.

The novel centers around a retired doctor's obsession with the life and works of Gustave Flaubert, a 19th-century French writer. The doctor's fascination leads him on a quest to find a stuffed parrot that once belonged to the writer. The novel is a blend of biography, literary criticism, and personal memoir, and it explores themes such as the nature of art and the difficulties of interpreting the past.

This novel is a unique blend of Eastern philosophy and Western literary technique, following the adventures of its protagonist, a British-educated Indian everyman, as he navigates the complexities of life. The narrative is filled with humor, satire, and linguistic playfulness, as the protagonist interacts with various eccentric characters and experiences numerous absurd situations. The book is a critique of both British colonialism and traditional Indian society, offering a distinctive and insightful perspective on the human condition.