A former FBI profiler, who is renowned for capturing a notorious serial killer, is lured out of retirement to track down a new killer who has a taste for families. The new killer, dubbed "The Tooth Fairy", is a complex character with a troubled past that leads him to commit his heinous crimes. As the profiler delves deeper into the investigation, he is forced to confront his own demons and the manipulative games of the serial killer he previously captured, who is now behind bars.

This series introduces readers to a world where vampires, werewolves, and other supernatural beings are legal citizens of the United States, and follows the life of Anita Blake, a professional zombie raiser, vampire executioner, and supernatural consultant for the police. Set in St. Louis, Missouri, Anita navigates the complexities of her personal and professional life, dealing with various supernatural mysteries, crimes, and often finding herself in the middle of vampire politics. As the series progresses, Anita's powers and relationships with the supernatural community grow, leading her into ever more dangerous and morally ambiguous situations. The blend of urban fantasy, horror, and mystery, along with a strong, complex female protagonist, has garnered a dedicated fan base.