Set in an alternate universe where Earth is known as "Antiterra," the novel follows the lives of Ada and Van, two wealthy siblings who fall into a passionate and incestuous love affair. Their relationship evolves over a span of 70 years, as they navigate through family secrets, personal tragedies, and the complex nature of time. The book is a blend of romance, science fiction, and philosophical exploration, all told through the author's signature wordplay and intricate narrative style.

"Claudine" is a series of four novels that narrate the life of a young woman named Claudine from her adolescence in a small French village, through her experiences at a Parisian boarding school, to her marriage and adult life in Paris. The novels are renowned for their vivid descriptions of the French countryside and the complex, sensual, and independent character of Claudine. They also explore themes of female sexuality, education, and the struggle for personal freedom in a restrictive society.

The novel is a historical fiction set in the early 1900s, which follows the journey of a 19-year-old woman who leaves her comfortable city life to become a teacher in a remote, impoverished mountain community in the Smoky Mountains of Tennessee. Through her experiences, she learns about the harsh realities of life, the power of faith, and the strength of the human spirit. Along the way, she also becomes torn between two men, a charismatic and passionate preacher and a pragmatic and grounded doctor.