"Station Eleven" is a post-apocalyptic novel that revolves around the lives of several characters before and after a devastating flu pandemic wipes out most of the world's population. The narrative jumps back and forth in time, exploring the interconnectedness of the characters' lives through their shared memories and experiences. The story also follows a traveling Shakespearean theatre company as they navigate the dangers of a collapsed civilization, emphasizing the importance of art and human connection in times of crisis.

The novel centers on a mysterious event in which the Earth is encapsulated by an alien barrier that drastically slows down time on the planet's surface compared to the rest of the universe. As stars disappear from the night sky, three childhood friends confront an altered reality where humanity must grapple with its insignificance in the cosmos. The narrative follows their personal journeys and the global response to this existential crisis, exploring themes of time, space, and the human condition, while scientists work fervently to understand and potentially reverse the effects of the time distortion before the outside universe ages eons, leaving Earth far behind.