The novel tells the story of Saleem Sinai, who was born at the exact moment when India gained its independence. As a result, he shares a mystical connection with other children born at the same time, all of whom possess unique, magical abilities. As Saleem grows up, his life mirrors the political and cultural changes happening in his country, from the partition of India and Pakistan, to the Bangladesh War of Independence. The story is a blend of historical fiction and magical realism, exploring themes of identity, fate, and the power of storytelling.

The novel is set during the Mexican Revolution, focusing on a whisky priest who is on the run from the authorities who have outlawed Catholicism. The priest, who is flawed and sinful, travels across the country to evade capture, minister to the faithful, and find a way to repent for his sins. Despite his moral failings, the priest's compassion and commitment to his faith make him a symbol of hope and resilience in the face of oppression. The book explores themes of faith, redemption, and the human struggle with sin.

The novel is set in London, 1945, during the final days of World War II. It revolves around a group of young women living in the May of Teck Club, a hostel for "the Pecuniary Convenience and Social Protection of Ladies of Slender Means below the age of Thirty Years." The narrative primarily focuses on their daily lives, their relationships, and their struggles to secure suitable husbands or lovers. The story is punctuated by a tragic event that leaves a lasting impact on the lives of these women.

The novel is an expansive tale set in the English town of Glastonbury, known for its mythical associations with the Holy Grail and King Arthur. It weaves together the lives of a vast array of characters, from industrialists to mystics, as they search for meaning and transcendence in the post-World War I era. The narrative delves into themes of spirituality, nature, and industrialization, contrasting the mystical allure of ancient legends with the stark realities of modern life. At its heart, the story is a quest for deeper understanding and connection, set against the backdrop of the town's legendary landscape and the annual pageant that reenacts its storied past.