The novel follows the journey of a young woman from rural Kentucky who, on her drive west to avoid an unwanted pregnancy, is unexpectedly entrusted with a three-year-old Native American girl. The protagonist settles in Tucson, Arizona, where she builds a non-traditional family with a group of resilient and unconventional women. The narrative explores themes of love, friendship, and the power of the human spirit while tackling issues of social injustice and immigration.

This novel follows the lives of four African-American women living in Phoenix, Arizona, each of whom is "holding their breath" as they navigate their personal and professional lives. The women are all in their mid-thirties, successful, and single, struggling to find love in a world that seems to offer few prospects. Through their friendship, they support each other and learn to let go of their pasts, "exhale", and move forward.

The novel follows the story of Codi Noline, a woman who returns to her hometown of Grace, Arizona to help her aging father. As she reconnects with her community and navigates her complicated relationship with her sister Hallie, who has disappeared in Nicaragua, Codi grapples with feelings of displacement and a lack of identity. The story explores themes of memory, heritage, love, and environmental conservation as Codi learns to find her place in the world and protect the land she calls home.