This novel explores the life of a young Barbadian-American girl growing up in Brooklyn during the Great Depression and World War II. The protagonist struggles with her identity as she navigates the cultural divide between her parents' traditional Barbadian values and her own American aspirations. The story delves into the themes of immigration, cultural identity, race, and gender, as the protagonist comes of age and seeks to establish her independence.

The novel explores the unlikely friendship between two Jewish boys in 1940s Brooklyn, New York. One is from a Hasidic background, steeped in religious tradition and destined to follow in his father's footsteps as a spiritual leader, while the other is the son of a secular Jewish intellectual, encouraged to think and question. Their bond is tested by their differing religious views, family expectations, and the external pressures of the surrounding world, including the aftermath of the Holocaust and the creation of the state of Israel. Through their relationship, the book delves into themes of faith, identity, father-son relationships, and the challenges of bridging different worlds and belief systems.

"Red at the Bone" is a multi-generational novel that explores the lasting impact of past decisions on the present and future. The story begins at a 16-year-old girl's coming-of-age ceremony in Brooklyn and then delves into the past, revealing the complex histories of her parents and grandparents. The narrative is a powerful exploration of identity, ambition, love, and the ways in which history and personal circumstances can shape a family's life.