This novel follows the story of Florentino Ariza and Fermina Daza, who fall passionately in love in their youth. However, Fermina eventually marries a wealthy doctor, leaving Florentino heartbroken. Despite this, Florentino remains devoted to Fermina for over fifty years, patiently waiting for her husband's death to have another chance at her love. The story is set against the backdrop of a cholera epidemic, serving as a metaphor for the transformative power of love and the destructive power of obsession.

"The Adventures and Misadventures of Maqroll" is a collection of seven novellas that follow the life of Maqroll, a seafarer and adventurer. The stories, set in various locations around the globe, are filled with philosophical musings, poetic language, and vivid descriptions of exotic locales. Maqroll's encounters with a host of characters, from pirates to prostitutes, and his experiences with love, loss, and loneliness, all contribute to a richly textured narrative that explores the human condition and the nature of existence.