Set in 1953, during the coronation of Queen Elizabeth II, the novel explores the life of a highly intelligent young woman, Frederica Potter, who aspires to attend the University of Cambridge. The narrative follows her struggles with the societal norms of post-war England, her family's expectations, and her own intellectual and emotional growth. Interwoven with Frederica's story is a parallel narrative about a theatrical production celebrating the coronation, which serves as a metaphor for the cultural and social changes occurring in England at the time.

The novel revolves around the complex relationship between Benna Carpenter, an aerobics instructor and Gerard, a college professor. Benna constantly imagines different scenarios and alternate lives for herself and Gerard, including one where they have a daughter. The narrative structure of the book is unique, with each chapter presenting a different 'anagram' or version of Benna's life, reflecting her chaotic and imaginative inner world.

The book is a poignant tale of love, life, and loss intertwined with the themes of food and kitchens. The narrative follows a young woman who, after the death of her grandmother, finds solace in the home of her friend and his transgender mother. As she navigates her grief, she also grapples with her growing feelings for her friend. The story explores the complexities of relationships, the concept of home, and the healing power of cooking.

"The Interestings" follows a group of six talented friends who meet at a summer camp for the arts in 1974. The novel spans over three decades, exploring their friendships, relationships, successes, and failures as they navigate adulthood. The story delves into themes of talent, envy, money, art, power, and the meaning of success as it examines how these friends' lives diverge and intersect over the years.