The book follows the life of Calliope Stephanides, a Greek-American hermaphrodite, who narrates her epic story starting from her grandparents' incestuous relationship in a small village in Asia Minor to her own self-discovery in 20th century America. The novel delves into themes of identity, gender, and the American dream, while also providing a detailed history of Detroit through the eyes of three generations of an immigrant family.

"Them" is a novel that chronicles the lives of the Wendall family, a lower-class family living in Detroit, over the course of three decades. The story, told from the perspective of three main characters, explores their struggles with poverty, violence, and a constant desire for a better life. It also delves into the societal issues of the time, including racial tensions and the disillusionment of the American Dream. The narrative is a gritty, realistic depiction of the hardships faced by many families in urban America during the mid-20th century.

The novel explores the intricate tapestry of women's experiences in the 1950s and 1960s, focusing on the coming-of-age story of a young woman as she navigates the challenges of friendship, love, and societal expectations. Set against the backdrop of the feminist and civil rights movements, the protagonist grapples with her desires for independence and artistic expression while confronting the constraints placed on her gender. Through her relationships with friends and lovers, she embarks on a journey of self-discovery, ultimately seeking to forge her own identity and a life that intertwines personal fulfillment with social activism.

The novel explores the emotional turmoil within an upper-middle-class family in the wake of a tragic boating accident that takes the life of one teenage son and leaves the other grappling with overwhelming guilt and depression. The story delves into the complexities of grief and the challenges of communication among family members as they struggle to support each other and cope with their individual pain. The narrative provides a poignant look at the ways in which ordinary people confront and navigate the extraordinary challenges of life, ultimately revealing the fragile yet resilient bonds of family.

The novel follows the story of a young Haitian girl who immigrates to Detroit, Michigan, with the hope of a new life and the American Dream, only to be confronted with the harsh realities of immigration and the struggles of adapting to life in America. Upon arrival, she is forced to live with her American cousins and navigate a world of culture clash, while dealing with the absence of her mother, who is detained by immigration authorities. The protagonist grapples with the challenges of fitting in, understanding her identity, and facing the gritty truths of her new neighborhood, all while holding onto her dreams and the spirit of her Haitian heritage.