The book follows the life of Calliope Stephanides, a Greek-American hermaphrodite, who narrates her epic story starting from her grandparents' incestuous relationship in a small village in Asia Minor to her own self-discovery in 20th century America. The novel delves into themes of identity, gender, and the American dream, while also providing a detailed history of Detroit through the eyes of three generations of an immigrant family.

The novel follows the story of a young Haitian girl who immigrates to Detroit, Michigan, with the hope of a new life and the American Dream, only to be confronted with the harsh realities of immigration and the struggles of adapting to life in America. Upon arrival, she is forced to live with her American cousins and navigate a world of culture clash, while dealing with the absence of her mother, who is detained by immigration authorities. The protagonist grapples with the challenges of fitting in, understanding her identity, and facing the gritty truths of her new neighborhood, all while holding onto her dreams and the spirit of her Haitian heritage.