The book follows the life of Calliope Stephanides, a Greek-American hermaphrodite, who narrates her epic story starting from her grandparents' incestuous relationship in a small village in Asia Minor to her own self-discovery in 20th century America. The novel delves into themes of identity, gender, and the American dream, while also providing a detailed history of Detroit through the eyes of three generations of an immigrant family.

"Them" is a novel that chronicles the lives of the Wendall family, a lower-class family living in Detroit, over the course of three decades. The story, told from the perspective of three main characters, explores their struggles with poverty, violence, and a constant desire for a better life. It also delves into the societal issues of the time, including racial tensions and the disillusionment of the American Dream. The narrative is a gritty, realistic depiction of the hardships faced by many families in urban America during the mid-20th century.

The novel explores the emotional turmoil within an upper-middle-class family in the wake of a tragic boating accident that takes the life of one teenage son and leaves the other grappling with overwhelming guilt and depression. The story delves into the complexities of grief and the challenges of communication among family members as they struggle to support each other and cope with their individual pain. The narrative provides a poignant look at the ways in which ordinary people confront and navigate the extraordinary challenges of life, ultimately revealing the fragile yet resilient bonds of family.