"Them" is a novel that chronicles the lives of the Wendall family, a lower-class family living in Detroit, over the course of three decades. The story, told from the perspective of three main characters, explores their struggles with poverty, violence, and a constant desire for a better life. It also delves into the societal issues of the time, including racial tensions and the disillusionment of the American Dream. The narrative is a gritty, realistic depiction of the hardships faced by many families in urban America during the mid-20th century.

The novel centers around an African American woman who is incarcerated in a mental institution for poisoning and castrating her lover. Through a series of flashbacks and introspective musings, the narrative delves into her troubled past, exploring themes of sexual and emotional abuse, racial oppression, and the protagonist's complex relationships with the men in her life. The story is a harrowing examination of the protagonist's psyche and the societal forces that have shaped her experiences, ultimately leading to her act of violence. The novel's fragmented structure and poetic prose challenge readers to piece together the reality of the protagonist's life and the events that led to her incarceration.

The novel explores the intricate tapestry of women's experiences in the 1950s and 1960s, focusing on the coming-of-age story of a young woman as she navigates the challenges of friendship, love, and societal expectations. Set against the backdrop of the feminist and civil rights movements, the protagonist grapples with her desires for independence and artistic expression while confronting the constraints placed on her gender. Through her relationships with friends and lovers, she embarks on a journey of self-discovery, ultimately seeking to forge her own identity and a life that intertwines personal fulfillment with social activism.

The novel explores the emotional turmoil within an upper-middle-class family in the wake of a tragic boating accident that takes the life of one teenage son and leaves the other grappling with overwhelming guilt and depression. The story delves into the complexities of grief and the challenges of communication among family members as they struggle to support each other and cope with their individual pain. The narrative provides a poignant look at the ways in which ordinary people confront and navigate the extraordinary challenges of life, ultimately revealing the fragile yet resilient bonds of family.