The book follows the lives of two Jewish cousins, one a skilled escape artist and the other a talented artist, before, during, and after World War II. They create a popular comic book superhero, which brings them fame and fortune. However, their success is complicated by personal struggles, including the escape artist's attempts to rescue his family from Nazi-occupied Prague and the artist's struggle with his sexuality. The narrative explores themes of escapism, identity, and the golden age of comic books.

"Underworld" is a sweeping narrative that spans from the 1950s to the end of the 20th century, exploring the interconnectedness of events and the impact of the Cold War on American society. The story revolves around a diverse group of characters, including a waste management executive, a graffiti artist, a nun, and a baseball collector, among others. These characters' lives intertwine in unexpected ways, illustrating the complex web of relationships and influences that shape our world. The novel is renowned for its vivid portrayal of historical events and its profound examination of themes such as memory, technology, and waste.

The book follows the life of Calliope Stephanides, a Greek-American hermaphrodite, who narrates her epic story starting from her grandparents' incestuous relationship in a small village in Asia Minor to her own self-discovery in 20th century America. The novel delves into themes of identity, gender, and the American dream, while also providing a detailed history of Detroit through the eyes of three generations of an immigrant family.

The novel is a final look into the life of Harry "Rabbit" Angstrom, a former high-school basketball star, now in his mid-fifties, overweight and grappling with several health issues. Despite his success in business, his personal life is in shambles, with his wife addicted to alcohol and his son to drugs. Harry, struggling with his mortality, is trying to understand his past and make sense of his future, while dealing with the changing American society and the consequences of his own choices.

Set in 1950s Knoxville, Tennessee, the novel follows the life of a man who has renounced his former existence of privilege to live among society's outcasts on the river. He is an educated man, who has chosen a life of fishing and surviving on the fringes of society. The narrative is filled with his encounters with various characters from the underbelly of the city, including criminals, prostitutes, and other outcasts. Despite his attempts to isolate himself, he finds himself drawn into the problems and tragedies of those around him.

The novel is a reimagining of Virginia Woolf's "Mrs. Dalloway" and follows three women from different time periods, each of whom are profoundly affected by Woolf's work. The narrative alternates between Virginia Woolf as she writes "Mrs. Dalloway" in 1923, a 1950s housewife who is reading the novel, and a contemporary woman who is essentially living the life of the titular character. These three storylines eventually converge in a powerful exploration of mental illness, sexuality, and the transcendent power of literature.