The novel follows the life of twin brothers born from a secret union between an Indian nun and a British surgeon in Ethiopia. Their mother dies during childbirth and their father disappears, leaving them to be raised by two doctors at the mission hospital where they were born. The story spans several decades and continents, and explores themes of love, betrayal, medicine, and the complexity of family ties. One of the brothers, a gifted surgeon, flees to America after a political revolution in Ethiopia, while the other remains and struggles with the challenges of practicing medicine in a developing country.

In this travel memoir, the author recounts an overland journey across Africa, starting from Cairo and ending in Cape Town. Along the way, he traverses a continent rich with diverse cultures, landscapes, and histories, while also confronting the stark realities of poverty, political turmoil, and the complex legacies of colonialism. His encounters with aid workers, missionaries, and locals provide a nuanced perspective on the challenges and beauty of Africa, as well as a critical look at the effects of foreign aid and development. The narrative is a blend of adventure, reflection, and social commentary, revealing the author's deep fascination with the continent and its people.