The book revolves around a young girl named Meggie and her father Mo, who possesses a unique ability to bring characters from books to life by reading aloud. This gift, however, comes with a price, as they are entangled in a dangerous adventure when a villain from a fantasy book called "Inkheart" is accidentally summoned into the real world. As they struggle to fix the chaos caused by this crossover, they must navigate a treacherous world of magic and betrayal, while attempting to thwart the villain's sinister plans and protect the balance between reality and the fantastical realms of literature.

The book is a whimsical fantasy novel that follows the adventures of a blue bear as he navigates a world filled with bizarre creatures and surreal landscapes. With half a life more than the usual allotment for his species, the protagonist recounts his experiences, which range from being raised by mini-pygmies to attending an academy for gifted creatures, and from escaping the clutches of a carnivorous island to befriending a sentient tornado. Each of his thirteen and a half lives is a unique tale of curiosity, learning, and survival, set in a richly imagined universe that defies the ordinary at every turn.