All My Puny Sorrows is a poignant exploration of the complex relationship between two sisters, one a successful concert pianist battling severe depression and the other a struggling writer trying to support her. The narrative delves into themes of mental illness, suicide, love, and the power of familial bonds. It grapples with the moral and ethical questions surrounding assisted suicide, the struggle to understand a loved one's pain, and the lengths to which one might go to help them find peace.

The novel explores the complex layers of identity, belonging, and the legacy of colonialism through the story of a French-Algerian family across three generations. It delves into the life of a young woman who grapples with her grandfather's painful past as a harki, an Algerian who fought for the French during the Algerian War of Independence. As she uncovers her family's history, she confronts the silence and trauma that have shaped their experiences of dislocation and cultural disconnection. The narrative weaves between past and present, revealing the enduring impact of historical events on individual lives and the struggle to reconcile with one's heritage in a modern world.