The novel is a comedic satire set in New Orleans in the early 1960s, centered around Ignatius J. Reilly, a lazy, eccentric, highly educated, and socially inept man who still lives with his mother. Ignatius spends his time writing a lengthy philosophical work while working various jobs and avoiding the responsibilities of adulthood. The story follows his misadventures and interactions with a colorful cast of characters in the city, including his long-suffering mother, a flamboyant nightclub owner, a beleaguered factory worker, and a frustrated hot dog vendor.

"The Adventures and Misadventures of Maqroll" is a collection of seven novellas that follow the life of Maqroll, a seafarer and adventurer. The stories, set in various locations around the globe, are filled with philosophical musings, poetic language, and vivid descriptions of exotic locales. Maqroll's encounters with a host of characters, from pirates to prostitutes, and his experiences with love, loss, and loneliness, all contribute to a richly textured narrative that explores the human condition and the nature of existence.

"Water Music" is a historical fiction novel that follows the adventures of two men, an explorer and a petty criminal, during the late 18th century. The narrative alternates between the perspectives of the explorer, who embarks on a quest to discover the source of the Niger River in Africa, and the criminal, who is trying to navigate the underbelly of London. The novel blends humor, rich historical detail, and adventure as it explores themes of ambition, survival, and the clash of cultures.