"11/22/63" is a science fiction novel by Stephen King that follows the story of Jake Epping, a high school English teacher who discovers a portal that leads to 1958. After being convinced by his friend Al to use the portal to prevent the assassination of John F. Kennedy, Jake embarks on a journey through time to change the course of history. Along the way, he falls in love with a woman named Sadie and faces various obstacles that threaten to alter the timeline he is trying to change. The book explores themes of love, loss, and the consequences of trying to change the past.

In the science fiction novel, a groundbreaking discovery of ancient human remains leads to the uncovering of a new, heretofore unseen stage of human evolution. Scientists grapple with the implications of a dormant virus that has suddenly awakened within human DNA, causing rapid, radical, and uncontrolled genetic mutations. As the virus spreads, society is thrown into chaos, with fear and uncertainty about the future of humanity. The protagonists, a molecular biologist and a paleontologist, race against time to understand the virus, known as "Darwin's Radio," and its potential to either doom or elevate the human race. Their journey is fraught with personal and professional challenges as they confront the possibility that evolution might be a much more active and immediate force than anyone had ever imagined.