"The Book of Daniel" is a semi-fictional novel that explores the lives of the Isaacson family, specifically focusing on the children, Daniel and Susan, after their parents, accused of being Communists, are executed. The narrative is a combination of historical fiction and a political commentary, providing a deep exploration of the Red Scare in the United States during the Cold War era. The novel is a critical examination of social, political, and familial dynamics in a time of national fear and paranoia.

The book tells the story of a young English boy, Rob Cole, in the 11th century who becomes an apprentice to a barber-surgeon. Rob's ambition to become a physician takes him across Europe and into the heart of the Muslim world, a journey fraught with danger and discovery. He disguises himself as a Jew to study at a school that does not admit Christians. The narrative is a captivating mix of history, science, and adventure, highlighting the protagonist's perseverance and the state of medical knowledge during the Middle Ages.

Set in the late 17th century, the novel explores the lives of French colonists in Quebec City. It focuses on the daily experiences of a French apothecary and his young daughter, illuminating their struggles and joys as they navigate the harsh realities of frontier life. The narrative delves into themes of faith, identity, and the human spirit's resilience, offering an intimate portrait of early colonial life in North America.

The novel follows the life of twin brothers born from a secret union between an Indian nun and a British surgeon in Ethiopia. Their mother dies during childbirth and their father disappears, leaving them to be raised by two doctors at the mission hospital where they were born. The story spans several decades and continents, and explores themes of love, betrayal, medicine, and the complexity of family ties. One of the brothers, a gifted surgeon, flees to America after a political revolution in Ethiopia, while the other remains and struggles with the challenges of practicing medicine in a developing country.