In the science fiction novel, a groundbreaking discovery of ancient human remains leads to the uncovering of a new, heretofore unseen stage of human evolution. Scientists grapple with the implications of a dormant virus that has suddenly awakened within human DNA, causing rapid, radical, and uncontrolled genetic mutations. As the virus spreads, society is thrown into chaos, with fear and uncertainty about the future of humanity. The protagonists, a molecular biologist and a paleontologist, race against time to understand the virus, known as "Darwin's Radio," and its potential to either doom or elevate the human race. Their journey is fraught with personal and professional challenges as they confront the possibility that evolution might be a much more active and immediate force than anyone had ever imagined.

The novel is a sprawling epic that spans the period from the 1893 World's Fair to the years following World War I. It follows the stories of several characters including the anarchist Traverse family, a group of balloonists, a detective, and a mathematician. The book explores themes of anarchism, capitalism, and technology, and incorporates elements of science fiction, adventure, and historical fiction. It is noted for its complex structure and dense, multifaceted narrative.

This science fiction novel revolves around the adventures of Martin Padway, a modern-day man who inexplicably finds himself transported to Rome during the 6th century. Faced with the decline of the Roman Empire, Padway uses his knowledge of history and modern technology to introduce innovations in an attempt to alter the course of history and prevent the onset of the Dark Ages. Through his efforts to implement social and technological advancements, he navigates the complexities of ancient politics, economics, and warfare, striving to create a better future. The story blends historical fiction with time travel, exploring themes of innovation, cultural exchange, and the impact of individual actions on the course of history.