The novel is a post-apocalyptic horror story that centers around a solitary man who may be the last human alive on earth after a pandemic has turned the rest of humanity into vampire-like creatures. He spends his days fortifying his home, hunting for food, and killing these creatures while they sleep. At night, he is tormented by their attempts to break into his home and kill him. His isolation drives him to the brink of insanity, and the novel explores themes of loneliness, survival, and the human capacity for hope in the face of utter despair.

In a future America where the federal government has largely collapsed and been replaced by corporate entities, a computer hacker and pizza delivery driver becomes embroiled in a plot involving a dangerous new drug and a computer virus called "Snow Crash". He is joined by a teenage skateboard courier and a host of other characters in a high-stakes race to uncover the truth behind the virus and its origins in ancient Sumerian culture. The narrative explores themes of linguistics, philosophy, computer science, religion, and cryptography.

The narrative unfolds through the lives of two siblings endowed with extraordinary powers, set against the backdrop of systemic racism and societal turmoil in America. The older brother's abilities emerge amidst the violence of the Los Angeles riots, while his younger sister's powers manifest as a form of telekinesis. As they navigate a world rife with injustice and the carceral state's oppressive reach, the siblings grapple with the potential and limitations of their gifts. The story is a searing exploration of anger, hope, and the indomitable spirit of resistance, examining whether supernatural abilities can be a catalyst for change in a world entrenched in institutionalized inequality.