The novel follows the story of a young woman who wins a guest editorship at a magazine in New York City and, after a series of personal and professional disappointments, suffers a mental breakdown and returns to her family, where she continues to struggle with depression and suicidal thoughts. The protagonist's experiences in psychiatric institutions and her attempts to reclaim her life are depicted with brutal honesty, making it a poignant exploration of mental illness and the societal pressures faced by women in the mid-20th century.

The novel is a final look into the life of Harry "Rabbit" Angstrom, a former high-school basketball star, now in his mid-fifties, overweight and grappling with several health issues. Despite his success in business, his personal life is in shambles, with his wife addicted to alcohol and his son to drugs. Harry, struggling with his mortality, is trying to understand his past and make sense of his future, while dealing with the changing American society and the consequences of his own choices.

The novel tells the story of Gogol Ganguli, a second-generation Indian-American, who struggles with his unique name and his dual cultural identity. Born to immigrant parents from Kolkata, India, Gogol is named after the famous Russian author, Nikolai Gogol, a decision that shapes his life in unexpected ways. As he grows up, he finds himself torn between his parents' traditional Indian values and his desire to fit into mainstream American society. This internal conflict is further complicated by his relationships with women of different cultural backgrounds. The book explores themes of identity, cultural assimilation, and the immigrant experience.

This novel is a contemporary, multicultural exploration of family life, love, and identity. It follows the lives of two mixed-race families, the Belseys and the Kipps, who are linked by their shared professions in academia and a complex web of marital and extramarital relationships. The story is set against the backdrop of Wellington, a fictional New England town, and explores themes of race, class, and cultural clash. It also delves into the world of academia, examining the politics and conflicts that arise in that environment.

The novel explores the complexities of marriage and divorce in the late 19th century through the story of Bartley and Marcia Hubbard, a young couple from a small New England town. As Bartley's journalistic career takes off, his moral shortcomings and infidelity strain the marriage, leading to a tumultuous relationship. The narrative delves into the social and personal consequences of their failing marriage, highlighting the challenges of adhering to societal expectations and the impact of personal choices on the lives of individuals and their communities. The book is a critical examination of the institution of marriage, the evolving roles of men and women, and the pursuit of happiness in the face of societal pressures.

The novel is a reflective account of the life of Harry Pulham, a middle-aged, conventional Bostonian who is prompted to examine his past and the choices he has made during the process of writing a Harvard class reunion biography. As he delves into his memories, he confronts his youthful ambitions, his experiences in World War I, and his complex relationships, particularly with a vivacious woman who challenged the conservative values of his upbringing. Through this introspection, Harry grapples with the realization that he has conformed to societal expectations at the expense of his own happiness, leading to a poignant exploration of the conflict between individual desires and societal pressures in early 20th-century America.

In "Boy, Snow, Bird," a young woman named Boy Novak escapes her abusive father in New York City to settle in a small town in Massachusetts, where she marries a widower and becomes stepmother to his daughter, Snow. After giving birth to her own daughter, Bird, who is dark-skinned, it is revealed that her husband and stepdaughter are light-skinned African Americans passing as white. The book explores themes of identity, beauty, and the damaging effects of racism as Boy grapples with her feelings towards Snow and Bird, and the societal implications of their different skin tones.

The novel delves into the lives of a family grappling with the impact of mental illness across generations. It explores the bonds and strains among family members as they confront the challenges posed by the eldest son's severe anxiety and depression. Through shifting perspectives, the narrative examines the ways in which each family member copes with their shared and individual struggles, illuminating the profound effects of love, loyalty, and the legacy of mental health issues on their relationships and choices. The story is a poignant and insightful portrayal of the complexities of familial love and the enduring human capacity for resilience in the face of emotional turmoil.