The book follows the life of Calliope Stephanides, a Greek-American hermaphrodite, who narrates her epic story starting from her grandparents' incestuous relationship in a small village in Asia Minor to her own self-discovery in 20th century America. The novel delves into themes of identity, gender, and the American dream, while also providing a detailed history of Detroit through the eyes of three generations of an immigrant family.

"Them" is a novel that chronicles the lives of the Wendall family, a lower-class family living in Detroit, over the course of three decades. The story, told from the perspective of three main characters, explores their struggles with poverty, violence, and a constant desire for a better life. It also delves into the societal issues of the time, including racial tensions and the disillusionment of the American Dream. The narrative is a gritty, realistic depiction of the hardships faced by many families in urban America during the mid-20th century.