The novel explores the life of an African-American man, Macon "Milkman" Dead III, from birth to adulthood. Set against the backdrop of racial tension in the mid-20th century United States, it delves into his journey of self-discovery and understanding his heritage. As Macon embarks on a literal and figurative journey south to reconnect with his roots, he encounters various characters that help him understand his family history and the power of community. The narrative is deeply rooted in African-American folklore and mythology, offering a profound commentary on identity, personal freedom, and the destructive power of racism.

The book follows the life of Calliope Stephanides, a Greek-American hermaphrodite, who narrates her epic story starting from her grandparents' incestuous relationship in a small village in Asia Minor to her own self-discovery in 20th century America. The novel delves into themes of identity, gender, and the American dream, while also providing a detailed history of Detroit through the eyes of three generations of an immigrant family.

"Them" is a novel that chronicles the lives of the Wendall family, a lower-class family living in Detroit, over the course of three decades. The story, told from the perspective of three main characters, explores their struggles with poverty, violence, and a constant desire for a better life. It also delves into the societal issues of the time, including racial tensions and the disillusionment of the American Dream. The narrative is a gritty, realistic depiction of the hardships faced by many families in urban America during the mid-20th century.

The novel explores the intricate tapestry of women's experiences in the 1950s and 1960s, focusing on the coming-of-age story of a young woman as she navigates the challenges of friendship, love, and societal expectations. Set against the backdrop of the feminist and civil rights movements, the protagonist grapples with her desires for independence and artistic expression while confronting the constraints placed on her gender. Through her relationships with friends and lovers, she embarks on a journey of self-discovery, ultimately seeking to forge her own identity and a life that intertwines personal fulfillment with social activism.