"Love Medicine" is a novel that explores the lives of several generations of a Native American family living on a reservation in North Dakota. The narrative is presented through a series of interconnected stories, each told from the perspective of different family members, and spans over 60 years, from 1934 to 1999. The book explores themes of love, family, identity, and the struggle between tradition and modernity. It provides a deep and poignant look into the complexities of Native American life and culture, and the challenges faced by the community.

A teenage boy navigates the complexities of life after his mother is brutally attacked on their reservation in North Dakota. As the legal system fails to bring justice due to jurisdictional issues, the boy takes matters into his own hands. The novel explores themes of tribal law, justice, and the transition into adulthood, all set against the backdrop of Native American culture and history.