The novel tells the story of Humbert Humbert, a man with a disturbing obsession for young girls, or "nymphets" as he calls them. His obsession leads him to engage in a manipulative and destructive relationship with his 12-year-old stepdaughter, Lolita. The narrative is a controversial exploration of manipulation, obsession, and unreliable narration, as Humbert attempts to justify his actions and feelings throughout the story.

Set in the 1980s at a small, affluent liberal arts college in New England, the novel captures the lives of a group of self-absorbed, hedonistic students as they navigate a world of casual sex, drug use, and apathy. Through a series of first-person narratives that often overlap and contradict each other, the story delves into the disaffected and aimless existence of these young adults, exploring themes of unrequited love, the search for identity, and the meaninglessness of the college social scene. The characters' intertwining relationships and the consequences of their actions paint a bleak picture of the disillusionment and moral ambiguity of the era.

"Affliction" is a powerful and haunting novel about a man named Wade Whitehouse, a small-town cop in New Hampshire, who descends into a spiral of violence and despair triggered by the fear of his own impotence. The narrative delves deep into Wade's past and present life, his struggles with alcoholism, his failed marriage and difficult relationship with his daughter, and his abusive father, all leading to a tragic and shocking climax. The book is a profound exploration of the struggle for self and identity in a harsh and unforgiving environment.

The novel intertwines two compelling narratives: one of a contemporary woman who, while on a work assignment to photograph a historic crime scene, grapples with her disintegrating marriage and an overpowering attraction to another man; and the other, a century-old tragedy of a Norwegian immigrant, whose jealousy and secrets lead to a shocking act of violence on the isolated island of Smuttynose. As the photographer delves deeper into the past, the stories converge, revealing the enduring consequences of love and jealousy.

The novel is a layered narrative that alternates between the protagonist, a writer, working on his novel in 1960s New Hampshire and the story within his novel set in 1930s New England. The protagonist's story explores his relationships with his family, friends, and fellow writers, while the story within the novel follows a young man's journey of self-discovery during the Great Depression. The book won the National Book Award for Fiction in 1975.