The novel is a first-person narrative, a monologue by a young Jewish man, Alexander Portnoy, who is speaking to his psychoanalyst. He shares his struggles with his identity as a Jewish man in America, his sexual fantasies and frustrations, his complex relationship with his overbearing mother, and his experiences of guilt and shame. The book uses humor and frank language to explore themes of identity, sexuality, and the Jewish experience in America.

"Growing Up" is a memoir that recounts the author's experiences growing up in America during the Great Depression and World War II. The author shares his journey from a poverty-stricken childhood in Virginia to becoming a successful journalist in New York. The narrative is filled with engaging anecdotes about his family, particularly his strong-willed mother, and the struggles they faced during these challenging times. The memoir is an exploration of the author's family history, personal growth, and the socio-political landscape of mid-20th century America.