This novel exposes the harsh conditions and exploited lives of immigrants in the United States in Chicago and similar industrialized cities. The protagonist, a young Lithuanian immigrant, works in the meatpacking industry and experiences the extreme poverty, poor working conditions, and lack of social services. The narrative explores the corruption of the American meatpacking industry in the early 20th century and the hardships faced by the working class, leading to significant public outcry that contributed to the passage of the Pure Food and Drug Act.

"Twenty Years at Hull-House" is a memoir that recounts the author's experiences co-founding and running a settlement house in a poverty-stricken, immigrant neighborhood in Chicago. The book details the struggles and triumphs of the community as they navigate social, economic, and cultural challenges, while also offering insight into the author's own evolution as a social reformer. Throughout, the author emphasizes the importance of empathy, understanding, and community engagement in addressing social inequality.

The book provides an in-depth exploration of the experiences of American Loyalists who were forced into exile following the American Revolution. It details their struggles and hardships as they sought to rebuild their lives in far-flung corners of the British Empire, including Canada, the Caribbean, Sierra Leone, and India. The book also examines the broader impact of this mass migration on the shaping of the British Empire and the early United States.