The novel explores the life of an African-American man, Macon "Milkman" Dead III, from birth to adulthood. Set against the backdrop of racial tension in the mid-20th century United States, it delves into his journey of self-discovery and understanding his heritage. As Macon embarks on a literal and figurative journey south to reconnect with his roots, he encounters various characters that help him understand his family history and the power of community. The narrative is deeply rooted in African-American folklore and mythology, offering a profound commentary on identity, personal freedom, and the destructive power of racism.

The book is a complex and multi-layered narrative that weaves together the memories of an elderly man named Alden Dennis Weer. As he reminisces about his life in a small Midwestern town, the story unfolds in a non-linear fashion, revealing a tapestry of seemingly mundane events that are imbued with subtle supernatural elements and dark undercurrents. The protagonist's recollections are filled with enigmatic characters and incidents, and as the narrative progresses, it becomes apparent that Weer's memory may be unreliable, leading the reader to question the nature of reality and the veracity of his account. The novel blends elements of fantasy, horror, and mystery, creating a haunting meditation on memory, mortality, and the human condition.

"World's End" is a multigenerational saga that takes place in upstate New York. The narrative alternates between the 17th century, where a Dutch estate is the setting for a brutal power struggle between a master and his rebellious servant, and the 1960s, where a young man struggles with his family's past and his own place in the world. The book explores themes of power, class, and the cyclical nature of history.

The novel is a sprawling epic that spans the period from the 1893 World's Fair to the years following World War I. It follows the stories of several characters including the anarchist Traverse family, a group of balloonists, a detective, and a mathematician. The book explores themes of anarchism, capitalism, and technology, and incorporates elements of science fiction, adventure, and historical fiction. It is noted for its complex structure and dense, multifaceted narrative.

"Entering Fire" is a dark, surreal exploration of the human psyche, set against the backdrop of 19th-century France. The story follows the life of a man obsessed with the bizarre and grotesque, as he delves into the world of sexual obsession, madness, and the grotesque. His journey takes him from the underbelly of Paris to the exotic landscapes of North Africa, as he seeks to understand the nature of desire and the limits of the human mind. The narrative is rich with historical detail and vivid, dreamlike imagery, creating a world that is at once fascinating and deeply disturbing.

"Meteor in the Madhouse" is a posthumously published collection of interconnected novellas that delve into the complexities of African American life and identity. The narrative weaves through the experiences of various characters, primarily focusing on the protagonist's reflections on his life, his relationships with others, and his quest for understanding amidst the chaos of the world around him. The book explores themes of memory, history, and the interplay of reality and fiction, all set against the backdrop of the civil rights movement and the rich cultural tapestry of African American heritage. Through lyrical prose and a non-linear structure, the work challenges readers to contemplate the nature of storytelling and the power of the human spirit to endure and make sense of life's tumultuous journey.