The novel is a final look into the life of Harry "Rabbit" Angstrom, a former high-school basketball star, now in his mid-fifties, overweight and grappling with several health issues. Despite his success in business, his personal life is in shambles, with his wife addicted to alcohol and his son to drugs. Harry, struggling with his mortality, is trying to understand his past and make sense of his future, while dealing with the changing American society and the consequences of his own choices.

Set in 1950s Knoxville, Tennessee, the novel follows the life of a man who has renounced his former existence of privilege to live among society's outcasts on the river. He is an educated man, who has chosen a life of fishing and surviving on the fringes of society. The narrative is filled with his encounters with various characters from the underbelly of the city, including criminals, prostitutes, and other outcasts. Despite his attempts to isolate himself, he finds himself drawn into the problems and tragedies of those around him.

The novel is a reimagining of Virginia Woolf's "Mrs. Dalloway" and follows three women from different time periods, each of whom are profoundly affected by Woolf's work. The narrative alternates between Virginia Woolf as she writes "Mrs. Dalloway" in 1923, a 1950s housewife who is reading the novel, and a contemporary woman who is essentially living the life of the titular character. These three storylines eventually converge in a powerful exploration of mental illness, sexuality, and the transcendent power of literature.

The novel follows the life of Dunstan Ramsay, a man haunted by a childhood accident that he believes he caused. The book explores his guilt and its impact on his life, as well as his relationships with others, including a woman he loves but cannot have, a brilliant but troubled friend, and a saintly fool. Throughout his life, Ramsay seeks redemption and understanding in the realms of history, mythology, and religion.

"The Clay Machine-gun" is a surreal and complex novel that explores the nature of reality and illusion. The story is set in post-Soviet Russia and follows a protagonist who has multiple identities, including a poet in 19th-century Russia, a 20th-century psychiatric patient, and a 21st-century advertising executive. The narrative moves between these identities and realities, blurring the lines between them and creating a layered and philosophical exploration of Russian society, identity, and the human psyche.

"Querelle" is a provocative novel set in the seedy port of Brest, where the protagonist, an amoral, bisexual sailor, engages in theft, drug dealing, and murder. The story explores themes of identity, sexuality, and power, presenting a dark and complex character study that challenges societal norms and expectations. The narrative is imbued with homoerotic undertones, reflecting the author's own experiences and perspectives as a gay man.

"Jerome" is a dark and unsettling novella that delves into the life of its eponymous protagonist, a reclusive, grotesque, and morbidly obese librarian who lives in a decrepit apartment. His existence is one of grim routine and perverse fantasies, as he harbors an unhealthy obsession with the young daughter of his landlord. The narrative explores the depths of Jerome's alienation and psychological torment, painting a bleak portrait of a man consumed by his own depravity and the suffocating confines of his solitary world. The book is a stark examination of loneliness, despair, and the human condition, rendered with a visceral intensity that leaves a lasting impression.