Set in an alternate universe where Earth is known as "Antiterra," the novel follows the lives of Ada and Van, two wealthy siblings who fall into a passionate and incestuous love affair. Their relationship evolves over a span of 70 years, as they navigate through family secrets, personal tragedies, and the complex nature of time. The book is a blend of romance, science fiction, and philosophical exploration, all told through the author's signature wordplay and intricate narrative style.

The novel follows the life of George Caldwell, a high school teacher in a small town in Pennsylvania, who is struggling with feelings of disappointment and failure. He is constantly compared to his father, a mythological centaur, symbolizing the conflict between the mundane and the extraordinary. The narrative alternates between the modern world and the mythological realm, exploring themes of identity, disillusionment, and the struggle between the human and the divine.

A gifted artist, Harriet Burden, frustrated by the lack of recognition she receives due to her gender, conducts an experiment where she presents her work under the guise of three male fronts. Her plan backfires when the third front, Rune, refuses to admit that the work was not his own. After Rune's sudden death, Burden reveals her experiment, but is met with skepticism and scorn. The novel explores themes such as gender bias in the art world, identity, perception, and the nature of art itself.