The book is a tale of two childhood friends, one of whom believes he is God's instrument. The story is set in a New England town during the 1950s and 1960s and follows the lives of the two boys, one small and with a strange voice, who has visions of his own death and believes he is an instrument of God, and the other, the narrator, who struggles with faith. The novel explores themes of faith, fate, and the power of friendship against a backdrop of historical and political events, including the Vietnam War.

The novel follows two Indian actors who miraculously survive a plane explosion, and as a result, find themselves embodying good and evil. As they navigate their new identities, the story also delves into the life of a prophet and his creation of a new religion in a city of sand. The narrative is a blend of fantasy and reality, exploring themes of identity, religion, and the immigrant experience, while also providing a controversial interpretation of Islamic faith and the life of Prophet Muhammad.

"Home" is a deeply emotional narrative that explores the themes of faith, redemption, and the complexity of family relationships. The story revolves around the Boughton family, particularly the prodigal son, Jack, who returns home after twenty years. His struggle to fit into the family and society, and his sister Glory's attempts to help him, form the crux of the story. The book delves into their past, revealing secrets and regrets, and provides a profound reflection on love, loss, and forgiveness.