The novel is a poignant exploration of a young African-American man's journey through life, where he grapples with issues of race, identity, and individuality in mid-20th-century America. The protagonist, who remains unnamed throughout the story, considers himself socially invisible due to his race. The narrative follows his experiences from the South to the North, from being a student to a worker, and his involvement in the Brotherhood, a political organization. The book is a profound critique of societal norms and racial prejudice, highlighting the protagonist's struggle to assert his identity in a world that refuses to see him.

The novel explores the spiritual isolation of misfits and outcasts in a small town of the U.S. South. Its protagonist is a deaf-mute who becomes the confidant for various troubled souls including a black physician, a bitter labor activist, a lonely young girl, and a struggling café owner. Each pours their heart out to him, but he remains unable to respond, reflecting the deep human need for connection and understanding.

"Another Country" is a profound exploration of racial, sexual, and creative issues in 1950s Manhattan. The story follows the lives of various characters, including a jazz drummer, a Southern white woman, and a black playwright, among others. As the narrative unfolds, it delves into their struggles with identity, prejudice, and interpersonal relationships, offering a raw and unflinching portrayal of America's social and cultural landscape during a time of intense change and conflict.

Set in Mississippi during the Great Depression, this novel follows the life of a young African American girl and her family who are struggling to maintain their integrity, pride, and independence in the face of racism and social injustice. The family owns a piece of land which provides them some protection from the harsh realities of racial discrimination. The story is a poignant exploration of how they navigate through a prejudiced society, face social and economic challenges, and fight to keep their land.

"Quicksand" is a semi-autobiographical novel about a mixed-race woman named Helga Crane who, feeling out of place in both African-American and white societies, embarks on a journey of self-discovery. From the Southern United States to Denmark and back, she struggles with racial identity, sexual repression, and societal expectations, eventually marrying a reverend and becoming disillusioned with her life as a preacher's wife in the rural South. The novel explores themes of racial identity, class, and gender in the early 20th century.